Journal: Journal of Proteome Research
Article Title: Mapping Proteolytic Processing in the Secretome of Gastric Cancer-Associated Myofibroblasts Reveals Activation of MMP-1, MMP-2, and MMP-3
doi: 10.1021/pr400270q
Figure Lengend Snippet: Increased MMP activity in vivo in xenografts containing CAMs. (A) In BALB/c nu/nu mice, MMP activity revealed by FMT imaging of MMPSense 750 FAST is increased in xenografts of gastric cancer MKN45 cells containing two different CAMs compared with MKN45 cells alone. (B) Representative FMT images of mice with xenografts of MKN45 cells alone (top row), MKN45 cells + CAM2 (middle row), and MKN45 cells + CAM1 (bottom row).
Article Snippet: Immunocompromised mice (6 weeks old, BALB/c nu/nu, Charles River, Wilmington, MA) with xenogafts of MKN45 cells with or without CAMs ( Methods) were used for imaging MMP-activity using MMPSense 750 FAST.
Techniques: Activity Assay, In Vivo, Imaging